Partenaires

CNRS Universite Grenoble Alpes UPS LaNEF INSA TOULOUSE EMFL NEXT

Accueil


Accueil du site > Evènements du laboratoire > Séminaires > Archives - Séminaires 2014 > Nanomagnetism of iron oxide nanoparticles into biological matrices

English

Nanomagnetism of iron oxide nanoparticles into biological matrices

  • 25/11/2014, Francisco Teran (IMDEA Nanociencia and Unidad Asociada de Nanobiotecnología, CNB-CSIC, Madrid, Spain)

Nanomagnetism of iron oxide nanoparticles into biological matrices.

 

IMDEA Nanociencia, 28049 Madrid, Spain
and Unidad Asociada de Nanobiotecnología, CNB-CSIC+iMDEA Nanociencia
28049 Madrid, Spain
 
 
Iron oxide nanoparticles have been rapidly incorporated into an increasing number of techniques in biology and medicine, acting as core elements in a number of therapeutic and diagnostic approaches due to their suitable structural, colloidal and magnetic properties. These applications mainly rely on their static and dynamic magnetic response, through which they can be remotely actuated as contrast agent, magnetically-guided carrier or heating mediator. However, little attention has been paid to understand the variation of the magnetic response of nanoparticles inside cells or tissues, despite of the remarkable changes reported to date. I will present some guidelines to analyze the influence of the biological matrix on the magnetism of iron oxide nanoparticles. For this aim, we have assessed the heating efficiency of magnetic colloids against nanoparticle aggregation, concentration and viscosity in order to mimic the fate of nanoparticles upon cell internalization. Understanding the physical reasons behind the variation of magnetic properties of IONP when are inside cells or tissues is crucial for an efficient clinical use as heating and/or contrast agents.